Wound Healing Effect of Amniocytes Derived from a Fetus with a Neural Tube Defect
نویسندگان
چکیده
Introduction In spina bifida the neural tube fails to close during the embryonic period and it is thought that exposure of the neural tube to the amniotic fluid during pregnancy causes additional neural damage (second hit hypothesis) [1]. Intra-uterine tissue engineering, using a biomaterial seeded with stem cells, might prevent this additional damage. For this purpose, autologous stem cells from the amniotic fluid is an attractive source. However, it is not known if amniotic fluid stem cells (AFSCs) from a fetus with a neural tube defect share the same characteristics as AFSCs from a healthy fetus. The aim of this study was to determine the wound healing effect of amniocytes derived from patients with a neural tube defect.
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